But, it’s clear that neurotransmitters play a role, at least for some people. Neurotransmitters The long-held idea that depression is caused by low levels of certain neurotransmitters (chemical messengers that communicate between neurons) has been debunked, according to a systematic review published in July 2022 in Molecular Psychiatry.Scientists think that while some genes may increase risk, other factors are needed to trigger symptoms. Genes alone are not believed to write your destiny, however. Genetics Many studies suggest that depression can spring from a genetic predisposition, including one international study involving more than 807,000 people, published in the February 2019 issue of the journal Nature Neuroscience, that linked 269 genes to depression.Psychiatrists today generally look at depression in “bio-psycho-social” terms, meaning that they see it as a complex disorder most likely triggered by overlapping biological, psychological, and social (also referred to as environmental) factors, according to a study published in August 2019 in Psychiatric Times.Īmong the potential contributors to depression are: And it’s well documented that once you’ve had one depressive episode, your risk of having another later in life increases. Depression can occur spontaneously, without any obvious cause. No one knows for sure why some people become depressed and others do not.
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